The purpose of this experiment was to learn about the electrophilic aromatic substitution reactions that take place on benzene, and how the presence of substituents in the ring affect the orientation of the incoming electrophile. Using acetanilide, as the starting material, glacial acetic acid, sulfuric acid, and nitric acid were mixed and stirred to produce p-nitroacetanilide. In a 125 mL Erlenmeyer flask, 3.305 g of acetanilide were allowed to mix with 5.0 mL of glacial acetic acid. This mixture was warmed in a hot plate with constantly stirring at a lukewarm temperature so as to avoid excess heating. If this happens, the mixture boils and it would be necessary to start the experiment all over again. After obtaining an homogeneous mixture, the flask was placed in an ice bath during five minutes next to a graduated cylinder containing 5.0 mL of concentrated sulfuric acid. The temperature of the ice bath was recorded to be 1.1 °C. Likewise, a second graduated cylinder containing 1.8 mL of nitric acid and 2.5 mL of sulfuric acid was immersed in the cold ice bath to keep the three different solutions at the same temperature. Thereafter, the cold 5.0 mL of H2SO4 were added to the erlenmeyer flask containing the acetanilide solution, which remained in the cold water for approximately another 4 minutes. The next step …show more content…
Nonetheless, the light yellow solid was purified by using the recrystallization technique. The formation of o-nitroacetanilide is inevitable and in order to eliminate it, 95% ethanol is used as the solvent of choice. The ortho isomer is soluble in the cold alcohol solution whereas p-nitroacetanilide in insoluble. As a result, the ortho isomer remains in the liquid solution and the final product, the p-nitroacetanilide is isolated with a final vacuum
Next, about 10 mL of both solutions, Red 40 and Blue 1, were added to a small beaker. The concentration of the stock solution were recorded, 52.1 ppm for Red 40 and 16.6 ppm for Blue 1. Then, using the volumetric pipette, 5 mL of each solution was transferred into a 10 mL volumetric flask, labelled either R1 or B1. Deionized water was added into the flask using a pipette until the solution level reached a line which indicated 10 mL. A cap for the flask was inserted and the flask was invented a few times to completely mix the solution. Then, the volumetric pipette was rinsed with fresh deionized water and
Experiment VIII was performed to analyze SN2 and SN1 using tertiary and primary substrates and use gas chromatography (GC) to examine the SN1 reaction. The product of the SN2 reaction was classified as n-butyl iodide by using infrared spectroscopy and gas chromatography mass spectroscopy and the product of the SN1 reaction was identified as of t-butyl chloride by using infrared spectroscopy and gas chromatography. For the SN2 reaction, 7.62 grams of n-butyl bromide, 20.0 grams of sodium iodide, and 79.1 grams of acetone were used to produce 3.12 grams of n-butyl iodide. The limited reagent was identified as n-butyl bromide and the theoretical yield of n-butyl iodide was calculated as 10.3 grams. The percent yield of this reaction was calculated
The most common atom to be replaced is a hydrogen atom, but occasionally other atoms may also be swapped out by an electrophile. Within this reaction, the substituents connected to the benzene ring demonstrate directing behavior that can affect the formation of the product. These substituents can either act as an ortho/para or meta director, which ultimately determine where the electrophile is added onto the ring. Figure 2. Bromine Production via Potassium Bromate and Hydrobromic Acid.1
Purpose: The main goal of this lab experiment is to synthesize acetylsalicylic acid through using different processes such as crystallization and filtration. Additionally, determining the purity of the synthesize product alongside with a commercial ASA provided in the lab, through using one of the melting point apparatus or conducting a USP test are also the objectives of this experiment. Results Discussion: As discussed in the lab manual, there are certain instructions which apply to proper measurement to provide accurate values throughout the experiments. For example, the transferring of 10 ml of ASA solution to a vial tube by volumetric pipette was necessary to acquire consistent results for our salicylic acid content.
The following lab period the solid was weighed (0.0483 g) and percent yield was calculated (65.5%) with the limiting reagent being tetraphenylcyclopentadienone. The melting point was determined. The first melting point was 204-204.9 °C and the second melting point was 215.6-215.9°C. Finally, an infrared spectroscopy was obtained for the
Glacial acetic acid and acetic anhydride were added to the mixture while refluxing, which converted the lime colored solution into a clear mixture. The flask was cooled in an ice bath and the solution
STEP FOUR: When all of the information has been sought through, we must analyze the information to create a Final
Nevertheless, the latter is not used in this experiment since it is very reactive and extremely flammable. On the contrary, NaBH4 is relatively mild and it can be used with protic solvents. In this manner, 1.507 grs of the ketone 9-fluorenone were mixed with 30.0 ml of 95% ethanol in a 125 ml Erlenmeyer flask. The bright yellow mixture was stirred during 7 minutes until all the components were dissolved.
The objective of this experiment was to use an aldol condensation reaction to synthesize 3-nitrochalcone from 3- nitrobenzaldehyde. This was accomplished with a Diels-Alder reaction that utilized 3-nitrobenzaldehyde, acetophenone, ethanol, and sodium hydroxide. The mechanism for the synthesis of 3-nitrochalcone is presented in Figures 1 and 2. The alpha carbon on the acetophenone is deprotonated. This is followed by the attack of the alpha carbon anion on the carbonyl carbon on the 3-nitrobenzaldehyde.
The temperature of the sulphuric acid was not measured throughout the experiment, however the room in which the experiment was conducted was kept constant, so the chance of any large error due to unknown temperature of the sulphuric acid was most likely reduced. The amount of sulphuric acid used was also controlled by measuring 100mL with a 100mL measuring cylinder to ensure that the results would be consistent. The volume of the agar cubes was calculated from the surface area of each agar cube, both before and after they had been in the sulphuric acid. This increased the reliability of the results as it allowed the rate of diffusion of the sulphuric acid into the agar cubes to be calculated more accurately. The concentration of the acid was 0.1M, which was placed in all three agar cubes to maintain consistency of results.
EXPERIMENTAL 2.1. Chemicals and solutions CuSO4·5H2O, 1,10-phenanthroline and other reagents are all analytical pure. All solutions were prepared with MilliQ water. The solutions were deaerated with high-pure nitrogen for 15min before use. 2.2.
Experiment 2 Report Scaffold (Substitution Reactions, Purification, and Identification) Purpose/Introduction 1. A Sn2 reaction was conducted; this involved benzyl bromide, sodium hydroxide, an unknown compound and ethanol through reflux technique, mel-temp recordings, recrystallization, and analysis of TLC plates. 2. There was one unknown compound in the reaction that was later discovered after a series of techniques described above.
Abstract – Methyl trans-cinnamate is an ester that contributes to the aroma of strawberry. It can be synthesized by an acid-catalyzed Fischer esterification of a methanol and trans-cinnamic acid under reflux. The solution was extracted to obtain the organic product, and evaporated residual solvent The yield was 68%, but there is some conflicting data regarding the purity. The melting point, IR, GC-MS indicate a highly pure desired product whereas 1H NMR shows there are unreacted reagents still present.
After 2.5 mL of NaOH had been added to the solution, the color of the solution remained blue for an acceptable amount of time. It was imperative for the experiment to be as fats as possible when performing this procedure, since there were times at which samples had to be collected. After completing this process the content of the Erlenmeyer falsk were disposed of in the halogenated waste container, and the Erlenmeyer flask was cleaned and prepared for the next steps. This same process of treating with acetone and titrating the solution was repeated at the 20, 35, and 50 minute mark, and the amounts of NaOH added to had to be recorded as well. Table 1.A was constructed in order to represent the resultant amounts of NaOH that were used and their respective time that they were added, as well as the amounts of sample and acetone that were mixed, and Calculations 1.A shows the calculations used to find the concentrations of HCl at different times, which is needed for the calculation of the rate constant.
Introduction The goal of the experiment is to examine how the rate of reaction between Hydrochloric acid and Sodium thiosulphate is affected by altering the concentrations. The concentration of Sodium thiosulfate will be altered by adding deionised water and decreasing the amount of Sodium thiosulphate. Once the Sodium thiosulphate has been tested several times. The effect of concentration on the rate of reaction can be examined in this experiment.